Tropism of engineered and evolved recombinant AAV serotypes in the rd1 mouse and ex vivo primate retina

There is much debate on the adeno-associated virus (AAV) serotype that best targets specific retinal cell types and the route of surgical delivery—intravitreal or subretinal. This study compared three of the most efficacious AAV vectors known to date in a mouse model of retinal degeneration (rd1 mou...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Hickey, D G, Edwards, T L, Barnard, A R, Singh, M S, de Silva, S R, McClements, M E, Flannery, J G, Hankins, M W, MacLaren, R E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746594/
https://ncbi.nlm.nih.gov/pubmed/28872643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2017.85
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