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Functional expression of complement factor I following AAV-mediated gene delivery in the retina of mice and human cells

Dry age-related macular degeneration (AMD) is characterised by loss of central vision and currently has no approved medical treatment. Dysregulation of the complement system is thought to play an important role in disease pathology and supplementation of Complement Factor I (CFI), a key regulator of...

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Bibliografiska uppgifter
I publikationen:Gene Ther
Huvudupphovsmän: Dreismann, Anna K., McClements, Michelle E., Barnard, Alun R., Orhan, Elise, Hughes, Jane P., Lachmann, Peter J., MacLaren, Robert E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2021
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149295/
https://ncbi.nlm.nih.gov/pubmed/33750925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-021-00239-9
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