An analysis of retinal gene therapy clinical trials: successful translation will depend on successful translation

Por MacLaren, Robert E
Publicado em 2009

Comment: Gene Therapy for Age-related Macular Degeneration

Por MacLaren, Robert E
Publicado no Lancet (2015)

Stem cells as a therapeutic tool for the blind: biology and future prospects

Por Singh, Mandeep S., MacLaren, Robert E.
Publicado em 2011

Recent advances and future prospects in choroideremia

Por Zinkernagel, Martin S, MacLaren, Robert E
Publicado no Clin Ophthalmol (2015)

Translating Induced Pluripotent Stem Cells from Bench to Bedside: Application to Retinal Diseases

Por Cramer, Alona O., MacLaren, Robert E.
Publicado em 2013

Induced pluripotent stem cell therapies for retinal disease

Por Comyn, Oliver, Lee, Edward, MacLaren, Robert E
Publicado em 2010

Gene therapy for retinal disease

Por McClements, Michelle E, MacLaren, Robert E
Publicado em 2013

Gene Therapy for Choroideremia Using an Adeno-Associated Viral (AAV) Vector

Por Barnard, Alun R., Groppe, Markus, MacLaren, Robert E.
Publicado no Cold Spring Harb Perspect Med (2015)

Selective Automated Perimetry Under Photopic, Mesopic, and Scotopic Conditions: Detection Mechanisms and Testing Strategies

Por Simunovic, Matthew P., Moore, Anthony T., MacLaren, Robert E.
Publicado no Transl Vis Sci Technol (2016)

Risks of gene therapy should be weighed against lack of alternatives for many diseases

Por MacLaren, Robert E, Ali, Robin R, Thrasher, Adrian J
Publicado em 2005

Unsutured phakic implantation of a black intraocular lens in the sulcus to treat leukocoria

Por Aslam, Sher A., Yusuf, Imran H., MacLaren, Robert E.
Publicado em 2014

Pathogenic mechanisms and the prospect of gene therapy for choroideremia

Por Dimopoulos, Ioannis S, Chan, Stephanie, MacLaren, Robert E, MacDonald, Ian M
Publicado no Expert Opin Orphan Drugs (2015)

A fragmented adeno-associated viral dual vector strategy for treatment of diseases caused by mutations in large genes leads to expression of hybrid transcripts

Por McClements, Michelle E., Charbel Issa, Peter, Blouin, Véronique, MacLaren, Robert E.
Publicado no J Genet Syndr Gene Ther (2016)

Rescue of the Stargardt phenotype in Abca4 knockout mice through inhibition of vitamin A dimerization

Por Charbel Issa, Peter, Barnard, Alun R., Herrmann, Philipp, Washington, Ilyas, MacLaren, Robert E.
Publicado no Proc Natl Acad Sci U S A (2015)

Hypotrichosis and juvenile macular dystrophy caused by CDH3 mutation: A candidate disease for retinal gene therapy

Por Singh, Mandeep S., Broadgate, Suzanne, Mathur, Ranjana, Holt, Richard, Halford, Stephanie, MacLaren, Robert E.
Publicado no Sci Rep (2016)

Inclusion of the Woodchuck Hepatitis Virus Posttranscriptional Regulatory Element Enhances AAV2-Driven Transduction of Mouse and Human Retina

Por Patrício, Maria I., Barnard, Alun R., Orlans, Harry O., McClements, Michelle E., MacLaren, Robert E.
Publicado no Mol Ther Nucleic Acids (2017)

Retinal Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia

Por Tolmachova, Tanya, Wavre-Shapton, Silene T., Barnard, Alun R., MacLaren, Robert E., Futter, Clare E., Seabra, Miguel C.
Publicado em 2010

Correlation of Optical Coherence Tomography and Autofluorescence in the Outer Retina and Choroid of Patients With Choroideremia

Por Xue, Kanmin, Oldani, Marta, Jolly, Jasleen K., Edwards, Thomas L., Groppe, Markus, Downes, Susan M., MacLaren, Robert E.
Publicado no Invest Ophthalmol Vis Sci (2016)

Non-Image-Forming Light Driven Functions Are Preserved in a Mouse Model of Autosomal Dominant Optic Atrophy

Por Perganta, Georgia, Barnard, Alun R., Katti, Christiana, Vachtsevanos, Athanasios, Douglas, Ron H., MacLaren, Robert E., Votruba, Marcela, Sekaran, Sumathi
Publicado em 2013

The Spectrum of CHM Gene Mutations in Choroideremia and Their Relationship to Clinical Phenotype

Por Simunovic, Matthew P., Jolly, Jasleen K., Xue, Kanmin, Edwards, Thomas L., Groppe, Markus, Downes, Susan M., MacLaren, Robert E.
Publicado no Invest Ophthalmol Vis Sci (2016)