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Functional expression of complement factor I following AAV-mediated gene delivery in the retina of mice and human cells

Dry age-related macular degeneration (AMD) is characterised by loss of central vision and currently has no approved medical treatment. Dysregulation of the complement system is thought to play an important role in disease pathology and supplementation of Complement Factor I (CFI), a key regulator of...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Gene Ther
Päätekijät: Dreismann, Anna K., McClements, Michelle E., Barnard, Alun R., Orhan, Elise, Hughes, Jane P., Lachmann, Peter J., MacLaren, Robert E.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2021
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC8149295/
https://ncbi.nlm.nih.gov/pubmed/33750925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41434-021-00239-9
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