Assessment of Tropism and Effectiveness of New Primate-Derived Hybrid Recombinant AAV Serotypes in the Mouse and Primate Retina

Adeno-associated viral vectors (AAV) have been shown to be safe in the treatment of retinal degenerations in clinical trials. Thus, improving the efficiency of viral gene delivery has become increasingly important to increase the success of clinical trials. In this study, structural domains of diffe...

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Bibliografiska uppgifter
Huvudupphovsmän: Charbel Issa, Peter, De Silva, Samantha R., Lipinski, Daniel M., Singh, Mandeep S., Mouravlev, Alexandre, You, Qisheng, Barnard, Alun R., Hankins, Mark W., During, Matthew J., MacLaren, Robert E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2013
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3621895/
https://ncbi.nlm.nih.gov/pubmed/23593201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0060361
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