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Autophagy flux inhibition, G2/M cell cycle arrest and apoptosis induction by ubenimex in glioma cell lines

This study aimed to investigate whether ubenimex could work as an anti-tumor drug alone in glioma cells and figure out the underlying potential mechanisms. Ubenimex is widely used as an adjunct therapy in multiple solid cancers. However, it is rarely used to treat glioblastoma. The function of ubeni...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Han, Liping, Zhang, Yongfei, Liu, Shuai, Zhao, Qingwei, Liang, Xianhong, Ma, Zhiguo, Gupta, Prakash K., Zhao, Miaoqing, Wang, Aihua
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5746103/
https://ncbi.nlm.nih.gov/pubmed/29296201
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.22594
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