Ubenimex enhances Brd4 inhibition by suppressing HEXIM1 autophagic degradation and suppressing the Akt pathway in glioma cells

Inhibition of Brd4 by JQ1 treatment showed potential in the treatment of glioma, however, some cases showed low sensitivity of JQ1. In addition, the pre-clinical analysis showed its limitation by demonstrating that transient treatment with JQ1 leads to aggressive tumor development. Thus, an improved...

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Publicado en:Oncotarget
Autores principales: Han, Liping, Zhao, Qingwei, Liang, Xianhong, Wang, Xiaoqing, Zhang, Zhen, Ma, Zhiguo, Zhao, Miaoqing, Wang, Aihua, Liu, Shuai
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542215/
https://ncbi.nlm.nih.gov/pubmed/28484091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17314
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