Ubenimex enhances Brd4 inhibition by suppressing HEXIM1 autophagic degradation and suppressing the Akt pathway in glioma cells

Inhibition of Brd4 by JQ1 treatment showed potential in the treatment of glioma, however, some cases showed low sensitivity of JQ1. In addition, the pre-clinical analysis showed its limitation by demonstrating that transient treatment with JQ1 leads to aggressive tumor development. Thus, an improved...

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Udgivet i:Oncotarget
Main Authors: Han, Liping, Zhao, Qingwei, Liang, Xianhong, Wang, Xiaoqing, Zhang, Zhen, Ma, Zhiguo, Zhao, Miaoqing, Wang, Aihua, Liu, Shuai
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5542215/
https://ncbi.nlm.nih.gov/pubmed/28484091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.17314
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