Structural basis for the species-selective binding of N,C-capped dipeptides to the Mycobacterium tuberculosis proteasome

The Mycobacterium tuberculosis (Mtb) 20S proteasome is vital for the pathogen to survive under nitrosative stress in vitro and to persist in mice. To qualify for drug development, inhibitors targeting Mtb 20S must spare both the human constitutive proteasome (c-20S) and immunoproteasome (i-20S). We...

Full description

Saved in:
Bibliographic Details
Published in:Biochemistry
Main Authors: Hsu, Hao-Chi, Singh, Pradeep K., Fan, Hao, Wang, Rong, Sukenick, George, Nathan, Carl, Lin, Gang, Li, Huilin
Format: Artigo
Language:Inglês
Published: 2016
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745808/
https://ncbi.nlm.nih.gov/pubmed/27976853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01107
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items