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Structural basis for the species-selective binding of N,C-capped dipeptides to the Mycobacterium tuberculosis proteasome
The Mycobacterium tuberculosis (Mtb) 20S proteasome is vital for the pathogen to survive under nitrosative stress in vitro and to persist in mice. To qualify for drug development, inhibitors targeting Mtb 20S must spare both the human constitutive proteasome (c-20S) and immunoproteasome (i-20S). We...
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| Publicado en: | Biochemistry |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5745808/ https://ncbi.nlm.nih.gov/pubmed/27976853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01107 |
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