Radiation Induces Diffusible Feeder Cell Factor(s) That Cooperate with ROCK Inhibitor to Conditionally Reprogram and Immortalize Epithelial Cells

Both feeder cells and Rho kinase inhibition are required for the conditional reprogramming and immortalization of human epithelial cells. In the present study, we demonstrated that the Rho kinase inhibitor Y-27632, significantly suppresses keratinocyte differentiation and extends life span in serum-...

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Publicado en:Am J Pathol
Main Authors: Palechor-Ceron, Nancy, Suprynowicz, Frank A., Upadhyay, Geeta, Dakic, Aleksandra, Minas, Tsion, Simic, Vera, Johnson, Michael, Albanese, Christopher, Schlegel, Richard, Liu, Xuefeng
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Investigative Pathology 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745544/
https://ncbi.nlm.nih.gov/pubmed/24096078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2013.08.009
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