ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells

We demonstrate that a Rho kinase inhibitor (Y-27632), in combination with fibroblast feeder cells, induces normal and tumor epithelial cells from many tissues to proliferate indefinitely in vitro, without transduction of exogenous viral or cellular genes. Primary prostate and mammary cells, for exam...

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Autors principals: Liu, Xuefeng, Ory, Virginie, Chapman, Sandra, Yuan, Hang, Albanese, Chris, Kallakury, Bhaskar, Timofeeva, Olga A., Nealon, Caitlin, Dakic, Aleksandra, Simic, Vera, Haddad, Bassem R., Rhim, Johng S., Dritschilo, Anatoly, Riegel, Anna, McBride, Alison, Schlegel, Richard
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2012
Matèries:
Regular Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349876/
https://ncbi.nlm.nih.gov/pubmed/22189618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.10.036
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