ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells

We demonstrate that a Rho kinase inhibitor (Y-27632), in combination with fibroblast feeder cells, induces normal and tumor epithelial cells from many tissues to proliferate indefinitely in vitro, without transduction of exogenous viral or cellular genes. Primary prostate and mammary cells, for exam...

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Autori principali: Liu, Xuefeng, Ory, Virginie, Chapman, Sandra, Yuan, Hang, Albanese, Chris, Kallakury, Bhaskar, Timofeeva, Olga A., Nealon, Caitlin, Dakic, Aleksandra, Simic, Vera, Haddad, Bassem R., Rhim, Johng S., Dritschilo, Anatoly, Riegel, Anna, McBride, Alison, Schlegel, Richard
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Investigative Pathology 2012
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Regular Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349876/
https://ncbi.nlm.nih.gov/pubmed/22189618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.10.036
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