ROCK Inhibitor and Feeder Cells Induce the Conditional Reprogramming of Epithelial Cells

We demonstrate that a Rho kinase inhibitor (Y-27632), in combination with fibroblast feeder cells, induces normal and tumor epithelial cells from many tissues to proliferate indefinitely in vitro, without transduction of exogenous viral or cellular genes. Primary prostate and mammary cells, for exam...

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Détails bibliographiques
Auteurs principaux: Liu, Xuefeng, Ory, Virginie, Chapman, Sandra, Yuan, Hang, Albanese, Chris, Kallakury, Bhaskar, Timofeeva, Olga A., Nealon, Caitlin, Dakic, Aleksandra, Simic, Vera, Haddad, Bassem R., Rhim, Johng S., Dritschilo, Anatoly, Riegel, Anna, McBride, Alison, Schlegel, Richard
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2012
Sujets:
Regular Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349876/
https://ncbi.nlm.nih.gov/pubmed/22189618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.10.036
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