Replacing mouse BAFF with human BAFF does not improve B-cell maturation in hematopoietic humanized mice

Hematopoietic humanized mice (hu-mice) have been developed to study the human immune system in an experimental in vivo model, and experiments to improve its performance are ongoing. Previous studies have suggested that the impaired maturation of human B cells observed in hu-mice might be in part due...

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Dettagli Bibliografici
Pubblicato in:Blood Adv
Autori principali: Lang, Julie, Zhang, Bicheng, Kelly, Margot, Peterson, Jacob N., Barbee, Jacob, Freed, Brian M., Di Santo, James P., Matsuda, Jennifer L., Torres, Raul M., Pelanda, Roberta
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2017
Soggetti:
Immunobiology and Immunotherapy
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745134/
https://ncbi.nlm.nih.gov/pubmed/29296925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017010090
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