Receptor editing and genetic variability in human autoreactive B cells

The mechanisms by which B cells undergo tolerance, such as receptor editing, clonal deletion, and anergy, have been established in mice. However, corroborating these mechanisms in humans remains challenging. To study how autoreactive human B cells undergo tolerance, we developed a novel humanized mo...

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Bibliographic Details
Published in:J Exp Med
Main Authors: Lang, Julie, Ota, Takayuki, Kelly, Margot, Strauch, Pamela, Freed, Brian M., Torres, Raul M., Nemazee, David, Pelanda, Roberta
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2016
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4710202/
https://ncbi.nlm.nih.gov/pubmed/26694971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151039
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