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Studies of lymphocyte reconstitution in a humanized mouse model reveal a requirement of T cells for human B cell maturation

The hematopoietic humanized mouse (hu-mouse) model is a powerful resource to study and manipulate the human immune system. However, a major and recurrent issue with this model has been the poor maturation of B cells that fail to progress beyond the transitional B cell stage. Interestingly, a similar...

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Detalhes bibliográficos
Main Authors: Lang, Julie, Kelly, Margot, Freed, Brian M., McCarter, Martin D., Kedl, Ross M., Torres, Raul M., Pelanda, Roberta
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3578183/
https://ncbi.nlm.nih.gov/pubmed/23335750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1202810
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