Replacing mouse BAFF with human BAFF does not improve B-cell maturation in hematopoietic humanized mice

Hematopoietic humanized mice (hu-mice) have been developed to study the human immune system in an experimental in vivo model, and experiments to improve its performance are ongoing. Previous studies have suggested that the impaired maturation of human B cells observed in hu-mice might be in part due...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Lang, Julie, Zhang, Bicheng, Kelly, Margot, Peterson, Jacob N., Barbee, Jacob, Freed, Brian M., Di Santo, James P., Matsuda, Jennifer L., Torres, Raul M., Pelanda, Roberta
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Immunobiology and Immunotherapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745134/
https://ncbi.nlm.nih.gov/pubmed/29296925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017010090
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