Replacing mouse BAFF with human BAFF does not improve B-cell maturation in hematopoietic humanized mice

Hematopoietic humanized mice (hu-mice) have been developed to study the human immune system in an experimental in vivo model, and experiments to improve its performance are ongoing. Previous studies have suggested that the impaired maturation of human B cells observed in hu-mice might be in part due...

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Bibliographische Detailangaben
Veröffentlicht in:Blood Adv
Hauptverfasser: Lang, Julie, Zhang, Bicheng, Kelly, Margot, Peterson, Jacob N., Barbee, Jacob, Freed, Brian M., Di Santo, James P., Matsuda, Jennifer L., Torres, Raul M., Pelanda, Roberta
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Immunobiology and Immunotherapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5745134/
https://ncbi.nlm.nih.gov/pubmed/29296925
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017010090
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