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Active PI3K abrogates central tolerance in high-avidity autoreactive B cells
Autoreactive B cells that bind self-antigen with high avidity in the bone marrow undergo mechanisms of central tolerance that prevent their entry into the peripheral B cell population. These mechanisms are breached in many autoimmune patients, increasing their risk of B cell–mediated autoimmune dise...
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| Publicado no: | J Exp Med |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6504226/ https://ncbi.nlm.nih.gov/pubmed/30948496 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20181652 |
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