Caricamento...

Activation of the MEK-ERK Pathway Is Necessary but Not Sufficient for Breaking Central B Cell Tolerance

Newly generated bone marrow B cells are positively selected into the peripheral lymphoid tissue only when they express a B cell receptor (BCR) that is nonautoreactive or one that binds self-antigen with only minimal avidity. This positive selection process, moreover, is critically contingent on the...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Greaves, Sarah A., Peterson, Jacob N., Torres, Raul M., Pelanda, Roberta
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2018
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5900439/
https://ncbi.nlm.nih.gov/pubmed/29686680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.00707
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !