LARG GEF and ARHGAP18 Orchestrate RhoA Activity to Control Mesenchymal Stem Cell Lineage

The quantity and quality of bone depends on osteoblastic differentiation of mesenchymal stem cells (MSCs), where adipogenic commitment depletes the available pool for osteogenesis. Cell architecture influences lineage decisions, where interfering with cytoskeletal structure promotes adipogenesis. Me...

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Udgivet i:Bone
Main Authors: Thompson, William R., Yen, Sherwin S., Uzer, Gunes, Xie, Zhihui, Sen, Buer, Styner, Maya, Burridge, Keith, Rubin, Janet
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743610/
https://ncbi.nlm.nih.gov/pubmed/29208526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2017.12.001
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