Mechanically Activated Fyn Utilizes mTORC2 to Regulate RhoA and Adipogenesis in Mesenchymal Stem Cells

Mechanical strain provides an anti-adipogenic, pro-osteogenic stimulus to mesenchymal stem cells (MSC) through generating intracellular signals and via cytoskeletal restructuring. Recently, mTORC2 has been shown to be a novel mechanical target critical for the anti-adipogenic signal leading to prese...

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Détails bibliographiques
Auteurs principaux: Thompson, William R., Guilluy, Christophe, Xie, Zhihui, Sen, Buer, Brobst, Kaitlyn E., Yen, Sherwin S., Uzer, Gunes, Styner, Maya, Case, Natasha, Burridge, Keith, Rubin, Janet
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040149/
https://ncbi.nlm.nih.gov/pubmed/23836527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.1476
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