Cell Mechanosensitivity to Extremely Low Magnitude Signals is Enabled by a LINCed Nucleus

A cell’s ability to recognize and adapt to the physical environment is central to its survival and function, but how mechanical cues are perceived and transduced into intracellular signals remains unclear. In mesenchymal stem cells (MSC), high magnitude substrate strain (HMS, ≥2%) effectively suppre...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Uzer, Gunes, Thompson, William R., Sen, Buer, Xie, Zhihui, Yen, Sherwin S., Miller, Sean, Bas, Guniz, Styner, Maya, Rubin, Clinton T., Judex, Stefan, Burridge, Keith, Rubin, Janet
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458857/
https://ncbi.nlm.nih.gov/pubmed/25787126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2004
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