Cell Mechanosensitivity to Extremely Low Magnitude Signals is Enabled by a LINCed Nucleus

A cell’s ability to recognize and adapt to the physical environment is central to its survival and function, but how mechanical cues are perceived and transduced into intracellular signals remains unclear. In mesenchymal stem cells (MSC), high magnitude substrate strain (HMS, ≥2%) effectively suppre...

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Publicado en:Stem Cells
Autores principales: Uzer, Gunes, Thompson, William R., Sen, Buer, Xie, Zhihui, Yen, Sherwin S., Miller, Sean, Bas, Guniz, Styner, Maya, Rubin, Clinton T., Judex, Stefan, Burridge, Keith, Rubin, Janet
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4458857/
https://ncbi.nlm.nih.gov/pubmed/25787126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2004
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