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Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution

Members of enzyme superfamilies specialize in different reactions but often exhibit catalytic promiscuity for one another's reactions, consistent with catalytic promiscuity as an important driver in the evolution of new enzymes. Wanting to understand how catalytic promiscuity and other factors...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Biol Chem
Main Authors: Sunden, Fanny, AlSadhan, Ishraq, Lyubimov, Artem, Doukov, Tzanko, Swan, Jeffrey, Herschlag, Daniel
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Biochemistry and Molecular Biology 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743071/
https://ncbi.nlm.nih.gov/pubmed/29070681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.788240
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