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Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution

Members of enzyme superfamilies specialize in different reactions but often exhibit catalytic promiscuity for one another's reactions, consistent with catalytic promiscuity as an important driver in the evolution of new enzymes. Wanting to understand how catalytic promiscuity and other factors...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:J Biol Chem
Κύριοι συγγραφείς: Sunden, Fanny, AlSadhan, Ishraq, Lyubimov, Artem, Doukov, Tzanko, Swan, Jeffrey, Herschlag, Daniel
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Biochemistry and Molecular Biology 2017
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743071/
https://ncbi.nlm.nih.gov/pubmed/29070681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.788240
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