Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution

Members of enzyme superfamilies specialize in different reactions but often exhibit catalytic promiscuity for one another's reactions, consistent with catalytic promiscuity as an important driver in the evolution of new enzymes. Wanting to understand how catalytic promiscuity and other factors...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Sunden, Fanny, AlSadhan, Ishraq, Lyubimov, Artem, Doukov, Tzanko, Swan, Jeffrey, Herschlag, Daniel
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Enzymology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743071/
https://ncbi.nlm.nih.gov/pubmed/29070681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.788240
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