FBW7 loss promotes chromosomal instability and tumorigenesis via Cyclin E1/CDK2-mediated phosphorylation of CENP-A

The centromere regulates proper chromosome segregation and its dysfunction is implicated in chromosomal instability (CIN). However, relatively little is known about how centromere dysfunction occurs in cancer. Here we define the consequences of phosphorylation by Cyclin E1/CDK2 on a conserved Ser18...

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發表在:Cancer Res
Main Authors: Takada, Mamoru, Zhang, Weiguo, Suzuki, Aussie, Kuroda, Taruho S., Yu, Zhouliang, Inuzuka, Hiroyuki, Gao, Daming, Wan, Lixin, Zhuang, Ming, Hu, Lianxin, Zhai, Bo, Fry, Christopher J., Bloom, Kerry, Li, Guohong, Karpen, Gary H., Wei, Wenyi, Zhang, Qing
格式: Artigo
語言:Inglês
出版: 2017
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743019/
https://ncbi.nlm.nih.gov/pubmed/28760857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1240
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