FBW7 loss promotes chromosomal instability and tumorigenesis via Cyclin E1/CDK2-mediated phosphorylation of CENP-A

The centromere regulates proper chromosome segregation and its dysfunction is implicated in chromosomal instability (CIN). However, relatively little is known about how centromere dysfunction occurs in cancer. Here we define the consequences of phosphorylation by Cyclin E1/CDK2 on a conserved Ser18...

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Bibliografiset tiedot
Julkaisussa:Cancer Res
Päätekijät: Takada, Mamoru, Zhang, Weiguo, Suzuki, Aussie, Kuroda, Taruho S., Yu, Zhouliang, Inuzuka, Hiroyuki, Gao, Daming, Wan, Lixin, Zhuang, Ming, Hu, Lianxin, Zhai, Bo, Fry, Christopher J., Bloom, Kerry, Li, Guohong, Karpen, Gary H., Wei, Wenyi, Zhang, Qing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743019/
https://ncbi.nlm.nih.gov/pubmed/28760857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1240
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