FBW7 loss promotes chromosomal instability and tumorigenesis via Cyclin E1/CDK2-mediated phosphorylation of CENP-A

The centromere regulates proper chromosome segregation and its dysfunction is implicated in chromosomal instability (CIN). However, relatively little is known about how centromere dysfunction occurs in cancer. Here we define the consequences of phosphorylation by Cyclin E1/CDK2 on a conserved Ser18...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Takada, Mamoru, Zhang, Weiguo, Suzuki, Aussie, Kuroda, Taruho S., Yu, Zhouliang, Inuzuka, Hiroyuki, Gao, Daming, Wan, Lixin, Zhuang, Ming, Hu, Lianxin, Zhai, Bo, Fry, Christopher J., Bloom, Kerry, Li, Guohong, Karpen, Gary H., Wei, Wenyi, Zhang, Qing
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5743019/
https://ncbi.nlm.nih.gov/pubmed/28760857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-17-1240
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