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Synaptotagmin-1 drives synchronous Ca(2+) triggered fusion by C(2)B domain-mediated synaptic vesicle-membrane attachment

The synaptic vesicle (SV) protein Synaptotagmin-1 (Syt1) is the Ca(2+) sensor for fast synchronous release. Biochemical and structural data suggest that Syt1 interacts with phospholipids and SNARE complex, but how these interactions translate into SV fusion remains poorly understood. Utilizing flash...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Nat Neurosci
Päätekijät: Chang, Shuwen, Trimbuch, Thorsten, Rosenmund, Christian
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742540/
https://ncbi.nlm.nih.gov/pubmed/29230057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-017-0037-5
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