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Synaptotagmin-1 drives synchronous Ca(2+) triggered fusion by C(2)B domain-mediated synaptic vesicle-membrane attachment

The synaptic vesicle (SV) protein Synaptotagmin-1 (Syt1) is the Ca(2+) sensor for fast synchronous release. Biochemical and structural data suggest that Syt1 interacts with phospholipids and SNARE complex, but how these interactions translate into SV fusion remains poorly understood. Utilizing flash...

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Detalhes bibliográficos
Publicado no:Nat Neurosci
Main Authors: Chang, Shuwen, Trimbuch, Thorsten, Rosenmund, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5742540/
https://ncbi.nlm.nih.gov/pubmed/29230057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41593-017-0037-5
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