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Synthetic Three-Component HIV-1 V3 Glycopeptide Immunogens Induce Glycan-Dependent Antibody Responses

Eliciting broadly neutralizing antibody (bNAb) responses against HIV-1 is a major goal for a prophylactic HIV-1 vaccine. One approach is to design immunogens based on known broadly neutralizing epitopes. Here we report the design and synthesis of an HIV-1 glycopeptide immunogen derived from the V3 d...

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Detalhes bibliográficos
Publicado no:Cell Chem Biol
Main Authors: Cai, Hui, Orwenyo, Jared, Giddens, John P., Yang, Qiang, Zhang, Roushu, LaBranche, Celia C., Montefiori, David C., Wang, Lai-Xi
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5741509/
https://ncbi.nlm.nih.gov/pubmed/29107699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2017.09.005
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