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Systematic Synthesis and Binding Study of HIV V3 Glycopeptides Reveal the Fine Epitopes of Several Broadly Neutralizing Antibodies

A class of new glycan-reactive broadly neutralizing antibodies represented by PGT121, 10-1074 and PGT128 has recently been discovered that target specific N-glycans and peptide region around the V3 domain. However, the glycan specificity and fine epitopes of these bNAbs remain to be further defined....

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Detalhes bibliográficos
Publicado no:ACS Chem Biol
Main Authors: Orwenyo, Jared, Cai, Hui, Giddens, John, Amin, Mohammed N, Toonstra, Christian, Wang, Lai-Xi
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518477/
https://ncbi.nlm.nih.gov/pubmed/28414420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00319
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