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A STAT3-dependent transcriptional circuitry inhibits cytotoxic gene expression in T cells
CD8(+) T cells are preprogrammed for cytotoxic differentiation in the thymus as they acquire expression of the transcription factor Runx3. However, a subset of effector CD8(+) T cells (Tc17) produce IL-17 and fail to express cytotoxic genes. Here, we show that the transcription factors directing IL-...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2017
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5740647/ https://ncbi.nlm.nih.gov/pubmed/29180433 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1711160114 |
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