A Thpok-directed transcriptional circuitry promotes Bcl6 and Maf to orchestrate T follicular helper differentiation.

The generation of high-affinity neutralizing antibodies, the objective of most vaccine strategies, occurs in B cells within germinal centers (GC) and requires rate-limiting ‘help’ from follicular helper CD4(+) T (Tfh) cells. Although Tfh differentiation is an attribute of MHC II-restricted CD4(+) T...

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Veröffentlicht in:Immunity
Hauptverfasser: Vacchio, Melanie S., Ciucci, Thomas, Gao, Yayi, Watanabe, Masashi, Balmaceno-Criss, Mariah, McGinty, Mitchell T., Huang, Allan, Xiao, Qi, McConkey, Cameron, Zhao, Yongmei, Shetty, Jyoti, Tran, Bao, Pepper, Marion, Vahedi, Golnaz, Jenkins, Marc K., McGavern, Dorian B., Bosselut, Rémy
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904114/
https://ncbi.nlm.nih.gov/pubmed/31422869
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2019.06.023
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