Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes

BACKGROUND: Histones undergo extensive post-translational modifications and this epigenetic regulation plays an important role in modulating transcriptional programs capable of driving cancer progression. Acetylation of histone H3K18, associated with gene activation, is enhanced by P300 and opposed...

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Udgivet i:BMC Cancer
Main Authors: Damodaran, Shivashankar, Damaschke, Nathan, Gawdzik, Joseph, Yang, Bing, Shi, Cedric, Allen, Glenn O., Huang, Wei, Denu, John, Jarrard, David
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738829/
https://ncbi.nlm.nih.gov/pubmed/29262808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3853-9
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