Loss of NAD-Dependent Protein Deacetylase Sirtuin-2 Alters Mitochondrial Protein Acetylation and Dysregulates Mitophagy

Aims: Sirtuins connect energy generation and metabolic stress to the cellular acetylome. Currently, only the mitochondrial sirtuins (SIRT3–5) and SIRT1 have been shown to direct mitochondrial function; however, Aims: NAD-dependent protein deacetylase sirtuin-2 (SIRT2), the primary cytoplasmic sirtui...

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Vydáno v:Antioxid Redox Signal
Hlavní autoři: Liu, Guoxiang, Park, Seong-Hoon, Imbesi, Marta, Nathan, William Joseph, Zou, Xianghui, Zhu, Yueming, Jiang, Haiyan, Parisiadou, Loukia, Gius, David
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc. 2017
Témata:
Original Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444513/
https://ncbi.nlm.nih.gov/pubmed/27460777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2016.6662
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