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Identifying Dysregulated Epigenetic Enzyme Activity in Castrate-Resistant Prostate Cancer Development

There is a tremendous need for novel strategies aimed at directly assessing activities of histone modifiers to probe epigenetic determinants associated with disease progression. Here, we developed a high-throughput peptide microarray assay to identify altered histone lysine (de)acetylation activity...

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Vydáno v:ACS Chem Biol
Hlavní autoři: Lee, Jin-Hee, Yang, Bing, Lindahl, Anastasia J., Damaschke, Nathan, Boersma, Melissa D., Huang, Wei, Corey, Eva, Jarrard, David F., Denu, John M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6594041/
https://ncbi.nlm.nih.gov/pubmed/28949514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.6b01035
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