Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes

BACKGROUND: Histones undergo extensive post-translational modifications and this epigenetic regulation plays an important role in modulating transcriptional programs capable of driving cancer progression. Acetylation of histone H3K18, associated with gene activation, is enhanced by P300 and opposed...

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Опубликовано в: :BMC Cancer
Главные авторы: Damodaran, Shivashankar, Damaschke, Nathan, Gawdzik, Joseph, Yang, Bing, Shi, Cedric, Allen, Glenn O., Huang, Wei, Denu, John, Jarrard, David
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2017
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5738829/
https://ncbi.nlm.nih.gov/pubmed/29262808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3853-9
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