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Distinct role of Sirtuin 1 (SIRT1) and Sirtuin 2 (SIRT2) in inhibiting cargo-loading and release of extracellular vesicles

Exosomes, vehicles for intercellular communication, are formed intracellularly within multivesicular bodies (MVBs) and are released upon fusion with the plasma membrane. For their biogenesis, proper cargo loading to exosomes and vesicle traffic for extracellular release are required. Previously we s...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Lee, Byung Rho, Sanstrum, Bethany J., Liu, Yutao, Kwon, Sang-Ho
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6934595/
https://ncbi.nlm.nih.gov/pubmed/31882861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-56635-0
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