The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations

Hypertrophic cardiomyopathy (HCM) is primarily caused by mutations in β-cardiac myosin and myosin-binding protein-C (MyBP-C). Changes in the contractile parameters of myosin measured so far do not explain the clinical hypercontractility caused by such mutations. We propose that hypercontractility is...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Nag, Suman, Trivedi, Darshan V, Sarkar, Saswata S, Adhikari, Arjun S, Sunitha, Margaret S, Sutton, Shirley, Ruppel, Kathleen M, Spudich, James A
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737966/
https://ncbi.nlm.nih.gov/pubmed/28481356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3408
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