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T7 RNA polymerase translocation is facilitated by a helix opening on the fingers domain that may also prevent backtracking
Here, we studied the complete process of a viral T7 RNA polymerase (RNAP) translocation on DNA during transcription elongation by implementing extensive all-atom molecular dynamics (MD) simulations to construct a Markov state model (MSM). Our studies show that translocation proceeds in a Brownian mo...
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| Publicado en: | Nucleic Acids Res |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5737862/ https://ncbi.nlm.nih.gov/pubmed/28575393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx495 |
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