T7 RNA polymerase translocation is facilitated by a helix opening on the fingers domain that may also prevent backtracking

Here, we studied the complete process of a viral T7 RNA polymerase (RNAP) translocation on DNA during transcription elongation by implementing extensive all-atom molecular dynamics (MD) simulations to construct a Markov state model (MSM). Our studies show that translocation proceeds in a Brownian mo...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: Da, Lin-Tai, E, Chao, Shuai, Yao, Wu, Shaogui, Su, Xiao-Dong, Yu, Jin
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Nucleic Acid Enzymes
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737862/
https://ncbi.nlm.nih.gov/pubmed/28575393
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx495
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