Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function

Granulocyte-macrophage colony-stimulating factor (GM-CSF) controls proliferation and survival of myeloid cells including monocytes. Here, we describe a time-dependent licensing process driven by GM-CSF in murine Ly6C(high) and human CD14(+) monocytes that disables their inflammatory functions and pr...

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Bibliografski detalji
Izdano u:Blood Adv
Glavni autori: Ribechini, Eliana, Hutchinson, James A., Hergovits, Sabine, Heuer, Marion, Lucas, Jörg, Schleicher, Ulrike, Jordán Garrote, Ana-Laura, Potter, Sarah J., Riquelme, Paloma, Brackmann, Heike, Müller, Nora, Raifer, Hartmann, Berberich, Ingolf, Huber, Magdalena, Beilhack, Andreas, Lohoff, Michael, Bogdan, Christian, Eyrich, Matthias, Hermanns, Heike M., Geissler, Edward K., Lutz, Manfred B.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2017
Teme:
Immunobiology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737598/
https://ncbi.nlm.nih.gov/pubmed/29296736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017006858
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