Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function

Granulocyte-macrophage colony-stimulating factor (GM-CSF) controls proliferation and survival of myeloid cells including monocytes. Here, we describe a time-dependent licensing process driven by GM-CSF in murine Ly6C(high) and human CD14(+) monocytes that disables their inflammatory functions and pr...

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Udgivet i:Blood Adv
Main Authors: Ribechini, Eliana, Hutchinson, James A., Hergovits, Sabine, Heuer, Marion, Lucas, Jörg, Schleicher, Ulrike, Jordán Garrote, Ana-Laura, Potter, Sarah J., Riquelme, Paloma, Brackmann, Heike, Müller, Nora, Raifer, Hartmann, Berberich, Ingolf, Huber, Magdalena, Beilhack, Andreas, Lohoff, Michael, Bogdan, Christian, Eyrich, Matthias, Hermanns, Heike M., Geissler, Edward K., Lutz, Manfred B.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2017
Fag:
Immunobiology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737598/
https://ncbi.nlm.nih.gov/pubmed/29296736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2017006858
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