Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4

The T helper 9 (Th9) cell transcriptional network is formed by an equilibrium of signals induced by cytokines and antigen presentation. Here we show that, within this network, two interferon regulatory factors (IRF), IRF1 and IRF4, display opposing effects on Th9 differentiation. IRF4 dose-dependent...

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Publicado no:Nat Commun
Main Authors: Campos Carrascosa, Lucia, Klein, Matthias, Kitagawa, Yohko, Lückel, Christina, Marini, Federico, König, Anika, Guralnik, Anna, Raifer, Hartmann, Hagner-Benes, Stefanie, Rädler, Diana, Böck, Andreas, Kang, Cholho, Lohoff, Michael, Garn, Holger, Schaub, Bianca, Berberich-Siebelt, Friederike, Sakaguchi, Shimon, Bopp, Tobias, Huber, Magdalena
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437292/
https://ncbi.nlm.nih.gov/pubmed/28497800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15366
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