Detection of wild-type EGFR amplification and EGFRvIII mutation in CSF-derived extracellular vesicles of glioblastoma patients

BACKGROUND: RNAs within extracellular vesicles (EVs) have potential as diagnostic biomarkers for patients with cancer and are identified in a variety of biofluids. Glioblastomas (GBMs) release EVs containing RNA into cerebrospinal fluid (CSF). Here we describe a multi-institutional study of RNA extr...

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Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Figueroa, Javier M, Skog, Johan, Akers, Johnny, Li, Hongying, Komotar, Ricardo, Jensen, Randy, Ringel, Florian, Yang, Isaac, Kalkanis, Steven, Thompson, Reid, LoGuidice, Lori, Berghoff, Emily, Parsa, Andrew, Liau, Linda, Curry, William, Cahill, Daniel, Bettegowda, Chetan, Lang, Frederick F, Chiocca, E Antonio, Henson, John, Kim, Ryan, Breakefield, Xandra, Chen, Clark, Messer, Karen, Hochberg, Fred, Carter, Bob S
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Basic and Translational Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5737576/
https://ncbi.nlm.nih.gov/pubmed/28453784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox085
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