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Pharmacokinetic interactions and dosing rationale for antiepileptic drugs in adults and children

AIMS: Population pharmacokinetic modelling has been widely used across many therapeutic areas to identify sources of variability, which are incorporated into models as covariate factors. Despite numerous publications on pharmacokinetic drug–drug interactions (DDIs) between antiepileptic drugs (AEDs)...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Br J Clin Pharmacol
Hauptverfasser: van Dijkman, Sven C., Rauwé, Willem M., Danhof, Meindert, Della Pasqua, Oscar
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5736836/
https://ncbi.nlm.nih.gov/pubmed/28815754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13400
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