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Single-molecule imaging reveals multiple pathways for the recruitment of translesion polymerases after DNA damage
Unrepaired DNA lesions are a potent block to replication, leading to replication fork collapse, double-strand DNA breaks, and cell death. Error-prone polymerases overcome this blockade by synthesizing past DNA lesions in a process called translesion synthesis (TLS), but how TLS polymerases gain acce...
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| Udgivet i: | Nat Commun |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5735139/ https://ncbi.nlm.nih.gov/pubmed/29255195 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02333-2 |
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