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A gatekeeping function of the replicative polymerase controls pathway choice in the resolution of lesion-stalled replisomes

DNA lesions stall the replisome and proper resolution of these obstructions is critical for genome stability. Replisomes can directly replicate past a lesion by error-prone translesion synthesis. Alternatively, replisomes can reprime DNA synthesis downstream of the lesion, creating a single-stranded...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Chang, Seungwoo, Naiman, Karel, Thrall, Elizabeth S., Kath, James E., Jergic, Slobodan, Dixon, Nicholas E., Fuchs, Robert P., Loparo, Joseph J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6926003/
https://ncbi.nlm.nih.gov/pubmed/31796591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1914485116
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