Single-molecule visualization of fast polymerase turnover in the bacterial replisome

The Escherichia coli DNA replication machinery has been used as a road map to uncover design rules that enable DNA duplication with high efficiency and fidelity. Although the enzymatic activities of the replicative DNA Pol III are well understood, its dynamics within the replisome are not. Here, we...

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Vydáno v:eLife
Hlavní autoři: Lewis, Jacob S, Spenkelink, Lisanne M, Jergic, Slobodan, Wood, Elizabeth A, Monachino, Enrico, Horan, Nicholas P, Duderstadt, Karl E, Cox, Michael M, Robinson, Andrew, Dixon, Nicholas E, van Oijen, Antoine M
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2017
Témata:
Biophysics and Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5419744/
https://ncbi.nlm.nih.gov/pubmed/28432790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23932
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