Polymerase exchange on single DNA molecules reveals processivity clamp control of translesion synthesis

Translesion synthesis (TLS) by Y-family DNA polymerases alleviates replication stalling at DNA damage. Ring-shaped processivity clamps play a critical but ill-defined role in mediating exchange between Y-family and replicative polymerases during TLS. By reconstituting TLS at the single-molecule leve...

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Detalhes bibliográficos
Main Authors: Kath, James E., Jergic, Slobodan, Heltzel, Justin M. H., Jacob, Deena T., Dixon, Nicholas E., Sutton, Mark D., Walker, Graham C., Loparo, Joseph J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4040570/
https://ncbi.nlm.nih.gov/pubmed/24825884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1321076111
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